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Journal Articles

PprI: A General switch responsible for extreme radioresistance of ${it Deinococcus radiodurans}$

Hua, Y.*; Narumi, Issei; Gao, G.*; Tian, B.*; Sato, Katsuya; Kitayama, Shigeru; Shen, B.*

Biochemical and Biophysical Research Communications, 306(2), p.354 - 360, 2003/06

https://doi.org/10.1016/S0006-291X(03)00965-3
 Times Cited Count：152 Percentile：95.76(Biochemistry & Molecular Biology)

We have identified a unique deinococcal gene, ${it pprI}$, as a general switch for downstream DNA repair and protection pathways, from a natural mutant, in which ${it pprI}$ is disrupted by a transposon. Complete functional disruption of the gene in wild-type leads to dramatic sensitivity to ionizing radiation. Radioresistance of the disruptant could be fully restored by complementation with ${it pprI}$. In response to radiation stress, PprI can significantly and specifically induce the gene expression of ${it recA}$ and ${it pprA}$ and enhance the enzyme activities of catalases. These results strongly suggest that PprI plays a crucial role in regulating multiple DNA repair and protection pathways in response to radiation stress.

Journal Articles

Recognition of DNA damage and induction of repair proteins in ${it Deinococcus radiodurans}$

Sato, Katsuya; Kikuchi, Masahiro; Narumi, Issei

JAERI-Conf 2002-005, p.172 - 184, 2002/03

https://jopss.jaea.go.jp/pdfdata/JAERI-Conf-2002-005.pdf

${it Deinococcus radiodurans possesses}$ a DNA damage response mechanism. However, the damage response is poorly understood in ${it D. radiodurans}$. By investigating the function of deinococcal proteins, we found that, unlike in ${it E. coli}$, LexA is not involved in the regulation of RecA in ${it D. radiodurans}$. This, in turn, led us to speculate that ${it D. radiodurans}$ has an alternative DNA damage response mechanism with which to control ${it recA}$ expression. Recently, we discovered that a novel protein regulates the expression of ${it recA}$ gene. The novel regulatory protein (designated as PprI) also control the induction of ${it pprA}$ gene following $$gamma$$ irradiation. Thus, ${it D. radiodurans}$ possesses unique mechanisms of DNA damage recognition and repair gene induction.

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